The Legacy Of Jackie Robinson Essay example -- Sports Baseball

The inheritance of Jackie Robinson goes past the April 15, 1947 evening at Ebbets Field, when the Brooklyn Dodger infielder turned into the main dark in the twentieth century to play baseball in the significant alliances. He changed the game, and he changed the disposition of many individuals in this nation, Jackie Robinson battled for all the individuals that were lucky, a great deal of them are, particularly the minority folks, to have the option to play in the significant groups and the effect on the ethnic minorities today. Robinson was a verifiably extraordinary player who had a portion of his greatest years taken from him. He was a speedster who driven his group to six World Series, won Rookie of the Year praises, a MVP grant and was a six-time All-Star. However, it’s not in light of his radiant vocation that Jackie’s number 42 is resigned in each significant class ballpark. It’s on the grounds that on a cold evening in 1947 at Ebbets Field, Robinson took the jewel for the Dodgers to turn into the primary dark man to play in a significant class ball game in the cutting edge period. His heavenly play and besides, his balance enduring an onslaught made ready for baseball incorporation, as obstructions separated in baseball, they likewise began to disintegrate in the public arena on the loose. While Jackie is best associated with coordinating significant group baseball, an occurrence that happened before his distinction as a Dodger proclaimed his future as a warrior in the fight for social liberties. America entered World War II, as in the greater part of America at that point; blacks endured the irateness of isolation. Jim...

Definitions in Psychology Theories and Research Methods

Definitions in Psychology Theories and Research Methods AP Psychology Identifications History Wilhelm Wundt-(1832-1920) He is the organizer of logical brain research since he was the primary individual to open a Psychology lab in 1879. Wundt is intently attached to structuralism which utilizes thoughtfulness to concentrate on the fundamental components of cognizance. Contemplation thoughtfulness is a path for individuals to search inside themselves and portray what they are feeling and thinking. Wundt utilized this strategy in the structuralism school of brain research so as to comprehend the structure of the psyche and to recognize the fundamental components of cognizance. William James-(1842-1910) He is an American Psychologist that is firmly connected with functionalism. He was keen on the capacity and reason for our social demonstrations and how they interlace with our condition. Functionalism-The functionalism side of brain science is centered around how our metal tasks help us to adjust to our condition. They utilized strategies, for example, continuous flow so as to help clarify our conduct. Max Wertheimer-(1880-1943) He is an analyst for the most part known for being an organizer of the Gestalt hypothesis who likewise made commitments to recognition, sensation and trial brain science. Sigmund Freud-(1856-1939) He was an Austrian Physician who is known for making the Psychoanalytic way to deal with brain research. He accepted that our activities and the manner in which we see things are directed by our oblivious. He likewise expressed that our brain was partitioned into 3 sections: the Id, Ego, and Superego. Psychoanalytic hypothesis This is Freud’s hypothesis that our musings and activities originate from our oblivious. He thought chatting with his patients over an extensive stretch of time could bring a portion of their oblivious recollections into light and assist them with conquering their battles. John Watson-(1878-1958) He was a behaviorist that is generally well known for his â€Å"Little Albert† test. He combined a white rodent with boisterous clamors and on account of this little Albert began crying and feared the rodent. He accepted this indicated our practices are totally learned. Ivan Pavlov-(1849-1936)He was a behaviorist that established the hypothesis of old style molding. He is generally known for his test with hounds in which he combined a tone with food which made a molded reaction to the tone (hound slobbering). B. F. Skinner-(1904-1990) Skinner was a behaviorist that established operant molding. He made a container (Skinner’s Box) in which rodents need to hit a bar for food. This crate shows that our conduct is significantly affected by the results after a conduct. Behaviorism-This is the point of view of brain research that thinks all that we do is an educated reaction to a circumstance. They just have confidence in target science and accordingly don't put stock in any of the psychological or oblivious procedures. Humanist viewpoint This point of view of brain science accepts we are on the whole great individuals and we simply need to meet our development potential. It additionally expresses that so as to proceed onward to the following degree of development the entirety of the necessities underneath it should be fulfilled. Psychoanalytic viewpoint This point of view of brain research is centered around how our contemplations and activities are a result of our oblivious sexual desires. It additionally centers around our improvement through the psycho sexual stages. Biopsychology (or neuroscience) viewpoint This point of view of brain research is centered around the connections of organic, neuroscience, conduct, and our mental procedures. Therapists in this field concentrate how our qualities and our condition associate. Developmental viewpoint This point of view centers around how normal choice has affected human practices and attributes and why we act as we do dependent on advancement. Social Perspective-This point of view of brain research just spotlights on detectable conduct and how we have figured out how to respond to various circumstances. Behaviorists don't trust in whatever goes on within the brain since they can't straightforwardly watch it. Psychological point of view This viewpoint of brain science concentrates how we encode, procedure, store, and recover data. By considering this they would like to figure out how we take care of issues, reason and respond to circumstances dependent on how we think. Social-social point of view This viewpoint of brain research is centered around how we are formed by our way of life and how our collaborations and convictions contrast from somebody with an alternate social foundation. Research Methods Knowing the past inclination in examine strategies, this is the propensity to accept that they realized something would happen from the beginning after they see the outcome. For instance, you anticipate the Mavericks were going to win yet they lost, after the game you will think, I realized they would lose on the grounds that their Point Guard was off all game. Applied research-Applied research is an exploration strategy used to discover answers for regular issues, for example, stress. Essential research-This examination technique is utilized to do inquire about for science itself and to achieve logical increase. Speculation In logical strategy, a speculation is a testable expectation frequently dependent on a hypothesis. Hypothesis In logical technique, a hypothesis is a perception that predicts practices or occasions. So as to test a hypothesis you should make a speculation dependent on the hypothesis you need to be tried. Operational definitions-In logical strategy, an operational definition are the arrangement of methodology used to characterize the examination factors. Legitimacy In the standards of test development, legitimacy is the means by which well the test can anticipate what it was intended to foresee. For instance, a driving test is utilized to test in the event that you realize the laws on driving and how to appropriately deal with a vehicle; this test is entirely solid in testing the subject it was intended to test. Unwavering quality In the standards of test development, dependability is the way reliable the scores on a test are. There are two different ways to test unwavering quality, you can have somebody step through the exam twice and perceive how the scores analyze or you can isolate the test by even and odd numbers and have them step through the two examinations. With both of these strategies the scores ought to be close if the test is dependable. Testing In inquire about techniques, an example is a segment of something that is utilized to speak to the whole of what is being inspected. The example is normally an irregular example since that generally will as a rule yield results pertinent to the whole of what is being examined. Populace In irregular inspecting, populace is the aggregate of the gathering you are considering. Generally testing or surveying a whole populace would take excessively long, that is the reason specialists frequently utilize arbitrary examining of the populace. Irregular determination In arbitrary inspecting, arbitrary choice is an example that precisely speaks to a whole populace since everybody has an equivalent possibility of being arbitrarily chosen. Defined inspecting in look into strategies, delineated examining is the point at which a populace is isolated dependent on rules, for example, sexual orientation, race or pay. After you have your populace arranged they are arbitrarily tested in every classification. Test In look into strategies, an analysis is the point at which a scientist controls the autonomous factors so as to influence the needy factors. Analyses are regularly used to discover circumstances and logical results. Perplexing factors In investigate techniques, frustrating factors are outside impacts other than the free factor. To forestall frustrating factors the experimenter must confine the factors that the members of the examination have. Task In look into strategies, task is the technique the analyst utilizes so as to allot the members of an analysis to a gathering. Irregular task in investigate strategies, arbitrary task is to allocate the members to an arbitrary gathering. This strategy will in general yield the most exact outcomes since everything is irregular. Experimenter inclination In investigate techniques, Experimenter predisposition is the point at which the scientist impacts the trial so as to acquire the outcomes he was searching for. To keep this from happening the specialist normally just watches the investigation and has no communication with it. Twofold visually impaired strategy In explore techniques, a twofold visually impaired system is an approach to forestall inclination in the analysis. When utilizing the twofold visually impaired technique neither the experimenters nor the members realize which bunch they are in. Member inclination (AKA reaction predisposition)- In inquire about strategies, member inclination is the propensity for the members to act the manner in which they think the analyst needs them to act. As a result of this information can be erroneous on the grounds that the individuals were reacting the manner in which they thought the experimenter needed, not the manner in which they really felt. Hawthorne impact In examine strategies, the Hawthorn impact is that when individuals realize that they are being watched they will in general change their conduct dependent on what they think the onlooker needs to see. Connection In look into techniques, connection is the relationship that two factors have. The relationship can quantify anyplace from - 1 to 1. - 1 and 1 are both exceptionally solid connections while 0 would be no relationship. Dissipate plot-In inquire about strategies, a disperse plot is a chart with various spots set on it. The dabs on a disperse plot could be truly close or truly spread separated. On the off chance that they are close there is a high relationship and in the event that they are spread separated there is a low connection. Overview technique In look into strategies, a study strategy is a technique for learning the practices of a particular gathering. This is for the most part done by scrutinizing a delegate test of a gathering so as to discover explicit data about the gathering being overviewed. Naturalistic perception In explore strategies, watching the subject in their characteristic living space without controlling the circumstance is called naturalistic perception. This is the best strategy to attempt to restrict the Hawthorne impact and get the best outcomes. Contextual investigation In look into strategies, a contextual investigation is the top to bottom concentrating of a particular

Subject Verb Agreement with Gerunds

Subject Verb Agreement with Gerunds Subject-Verb Agreement and GerundsWhen I check a students writing for the first time, I am almost guaranteed to spot a few errors related tosubject-verb agreement.Most of these errors are fairly easy for students to identify when proofreading their work, but one type of subject-verb agreement error is difficult for even advanced students to grasp. That type of error relates togerunds as subjects.Understand that a gerund is derived from a verb but functions as a noun ending in -ing. As in:Joggingis my favorite type of exercise.Shoppingfor my sister is quite difficult.Jogging and shopping look a lot like verbs, but function as nouns. Therefore, we need to pick the right verb later in the sentence.Heres what you need to remember: For the purpose of subject-verb agreement,gerunds should be treated as a singular noun(I usually ask my students to treat them like it). In this sentence we must say jogging is and shopping is. We must not say jogging are and shopping are.ExampleHeres a sentenc e I got today:The lecturer, on the other hand, posits that finding a lot of incomplete fossils are better than finding only a few complete ones.Can you see the error? Yes, this should be:The lecturer, on the other hand, posits that finding a lot of incomplete fossilsisbetter than finding only a few complete ones.The gerund is finding, so the proper verb choice is is. This was difficult for the student because there are a lot of words between the gerund (finding) and the verb (is). This is something you need to watch for when you proofread your work.ExceptionsAs always in English, there are exceptions. Some gerundscan be countableand this will have a plural form. For a list of those, consultthis page.Sign up for express essay evaluation today!Submit your practice essays for evaluation by the author of this website. Get feedback on grammar, structure, vocabulary and more. Learn how to score better on the TOEFL. Feedback in 48 hours.Sign Up Today

Annotated Bibliography On How Uniform Policy Swept U.s.

Annotated Bibliography Chandler, M. A. (2015, Oct 01). No uniform policy on what to wear. Washington Post Retrieved from http://sks.sirs.com.nauproxy01.national.edu In the Washington Post newspaper article stated the claim of how uniform policy swept U.S. in the school year of 2011-2012 to improve academics for the lacking students. Chandler says that according to federal data 20 percent of school districts made it necessary for students to wear uniforms. The uniform take-over caught the attention of researcher and educators of the benefits surrounding uniforms between high and low poverty school. Chandler is a journalist on education for the Washington Post. No uniform policy on what to wear offer reasonable evidence supporting school uniforms. Chandler showed experience in this journal. The author presented factual statements, analysis, and testimony of a mother with a low-income household. This newspaper fits the requirements of my assignment due to the testimony was given by a mother of six children with a low-income household. Also, with encouragement; the present of the United State idealizing the uniform policy. Dalton, R., and Virginia Wilkins. (2011, Oct 28). The way to really stop school bullying: Student mentors. Christian Science Monitor Retrieved from http://sks.sirs.com.nauproxy01.national.edu The effectiveness, bullying caused in the U.S. school district caused low attendance, grades, and graduation rates. A study conducted in the article show thatShow MoreRelatedLibrary Management204752 Words   |  820 PagesLibrary and Information Center Management Recent Titles in Library and Information Science Text Series Library and Information Center Management, Sixth Edition Robert D. Stueart and Barbara B. Moran United States Government Information: Policies and Sources Peter Hernon, Harold C. Relyea, Robert E. Dugan, and Joan F. Cheverie Library Information Systems: From Library Automation to Distributed Information Access Solutions Thomas R. Kochtanek and Joseph R. Matthews The Complete Guide to Acquisitions

Top 100 Inventions Made in Canada

Descartes’ Dualistic Conception of Human Nature Free Essays

Descartes’ Dualistic Conception of Human Nature Descartes’ dualistic concept of human nature looks at two different aspects of all humankind: our mind and our body. These aspects are the exact opposite of one another. Our mind allows us to think the thoughts we have every day, and our body allows us to do the physical things within our day to day lives. We will write a custom essay sample on Descartes’ Dualistic Conception of Human Nature or any similar topic only for you Order Now Descartes came to this dualistic concept by using his theory of methodological doubt. The theory involved thinking about anything and everything he was ever taught. By thinking these things, he came to realize that many things he was told have been false, so he went back to the beginning. He did this by doubting everything he ever thought was true, to find at least one thing he could not doubt. When finally reaching that one truth, he was able to use it to be the foundation when furthering his search to find more things he could not possibly doubt. The first truth he was able to come to was something he referred to as â€Å"cogito ergo sum†(I think therefore I am). The cogito basically states that we are existing to the point in which we can think; however, when looking at the body (physical substance) we cannot be entirely certain that this is real in the sense that the physical things around us can all be imagined with the use of our minds. The thinking aspect of our dualistic selves can be making us believe the things we see or feel; therefore, we can doubt the physical. At the same, time we know we are thinking, so we cannot doubt the mind. This leads to Descartes’ concept of how these two aspects are totally different. When looking at the physical and mental substances, one can see where Descartes is coming from. The mind can play tricks on us and make us believe that something is real and/or there when it really is not. There can be some sort of â€Å"puppet master† making us believe the physical things around us are real; however, when looking at the mind, we can argue that the mind, itself, is made up physical substance. Since the mind is in fact made up of physical substance, can it not be doubted as well? Can the â€Å"puppet master† not also be making us believe what we think is actually real? With the questions of doubting our mind, I come to my conclusion that Descartes’ theory of methodological doubt in the sense of the mind and the body being two distinct characteristics of mankind, is in fact right; however, I do not think the part stating that we can doubt the physical substance (the body) is correct. If we were going to doubt all the physical substances in our life, we would also have to doubt our mind, which in turn would lead us to doubting almost every thought we have within our lifetime. Doubting some thoughts may lead us to great discoveries to help us figure out human nature; however, I do believe doubting every thought we have will only do us harm by causing us to push everything and everyone out of our lives. When this happens, we will not be happy–happiness is after all, what separates man from every other living thing in the world. How to cite Descartes’ Dualistic Conception of Human Nature, Essay examples

On A Road To Heritage Essays - Everyday Use, Cultural Heritage

On A Road To Heritage On the Road to Heritage A key factor in Alice Walker's ?Everyday Use,? and Amy Tan's ?A Pair of Tickets,? is heritage. Throughout both stories the use of heritage can be seen easily. Walker's avoidance of heritage in her writings and Tan's understanding of heritage in her writing. Through this readers can see the true meaning of heritage. Understanding both sides of these two stories gives readers a chance to explore their own heritage and reflect on how they accept their past. By contrasting the family characters in ?Everyday Use,? Walker illustrates lost heritage by placing the significance of heritage solely on material objects. Walker presents Mama and Maggie, the younger daughter, as an example that heritage in both knowledge and form passing from one generation to another through a learning experience connection. However, by a broken connection, Dee the older daughter, represents a misconception of heritage as material. Dee, the ?heritage queen? portrays a rags to riches daughter who does not understand what heritage is all about. Her definition of heritage hangs on a wall to show off, not to be used. Dee's avoidance of heritage becomes clear when she is talking to Mama about changing her name, she says, ?I couldn't bear it any longer being named after the people who oppress me? (Walker 75). Thus resembling that Dee just takes another name without even understanding what her original name means. She tries to explain to Mama that her name now has meani ng, quality, and heritage; never realizing that the new name means nothing. Changing her name bothers Mama and Maggie because Dee's name is a fourth generation name, truly giving it heritage. Dee likes to gloat to her friends about how she was raised, so she tries to show off by decorating her house with useful items from her past. Her argument with Mama about taking quilts that were hand stitched as opposed to sewn by machine gives readers a chance to see Dee's outlook of heritage is short lived. Dee says to Mama, ?But they're priceless. . . Maggie would put them on the bed and in five years they'd be in rags. Less than that!? (Walker 77). Mama will not allow her daughter to take the quilts because she has been saving them for Dee's sister, Maggie, and she wants the quilts to be put into everyday use. By helping and living with Mama, Maggie uses the hand-made items in her life, experiences the life of her ancestors, and learns the history of both, exemplified by Maggie's knowledge of the hand-made items and the people who made them?a knowledge in which Dee does not possess. Dee attempts to connect with her heritage by taking ?picture after picture of me sitting there in front of the house. . . She never takes a shot without making sure the house is included? (Walker 74). Therefore showing Dee's quest for heritage is external, wishing to have these various items in order to display them in her home. She wants these items because she perceives each to have value, as shown in the argument yet again. Mama finally realizes that Dee does not understand her heritage when she says, ?This was Maggie's portion. This was the way she knew God to work? (Walker 77). She allowed Dee to run over her enough, and now she would not allow her foolish behavior to carry on, because heritage needs to be put to everyday use and not just be hung up on a wall for people to see. After Mama gives Maggie the quilts, Dee says, ?You just don't understand Your heritage? (Walker 77). Dee bel ieves heritage to be the quilt on the wall or the churn in the alcove. She knows the items are hand-made, but she does not know the knowledge and history behind the items. Yet, Mama does know the knowledge and history and she also knows that Maggie does too. Ironically, Dee criticizes Mama for not understanding heritage when, in fact, Dee fails to understand heritage herself. Throughout this story, heritage is understood by two characters and avoided by one character. Readers can understand that now there are two different meanings of heritage, one being everyday

Free Essays on Nixon

Richard Nixon’s Influence Upon Foreign Policy Foreign policy is the principle and activities that constitute the role of the United States in relation to the rest of the world. Foreign policy includes international matters, like participation in NATO, trade agreements, and maintaining peaceful relations with other countries. The primary goal of Foreign policy is National security because it holds the security of the United States, its citizens and their property. With Foreign policy the United States is able to keep international security and give economic aid to other countries. The head of Foreign policy is the President of the United States. The President has the power, granted by the Constitution, to be the commander in chief of all United States forces. He can enact treaties and meet with foreign leaders. Of our many presidents, Richard Milhous Nixon was considered to be an expert on Foreign policy. ( ) Nixon, our 37th president, was born in 1913 in Yorba Linda, California. He attended Duke University where he received a degree in Law. He served as a Congressman and Senator for his California district. Two years later in 1952, General Eisenhower chose Nixon, to be his running mate. As Vice President, Nixon took on major duties in the Eisenhower Administration. Much of his term was spent on trips abroad as a goodwill ambassador meeting with foreign leaders to discuss world problems, representing the President to Congress, and to help mend ties between opposing countries. He was also a target for anti-American protestors. One of Nixon’s most memorable trips was to the USSR, to help open a United States exhibition in Moscow. Escorted by Nixon, Soviet Premier Nikita Khrushchev was taken through a model of an American kitchen. While walking through the kitchen both men began to discuss the relative merits of the United States and systems of Communism. This discussion would later o n be noted as the â€Å"Kitchen Debate.† ( ) In t... Free Essays on Nixon Free Essays on Nixon Richard Nixon’s Influence Upon Foreign Policy Foreign policy is the principle and activities that constitute the role of the United States in relation to the rest of the world. Foreign policy includes international matters, like participation in NATO, trade agreements, and maintaining peaceful relations with other countries. The primary goal of Foreign policy is National security because it holds the security of the United States, its citizens and their property. With Foreign policy the United States is able to keep international security and give economic aid to other countries. The head of Foreign policy is the President of the United States. The President has the power, granted by the Constitution, to be the commander in chief of all United States forces. He can enact treaties and meet with foreign leaders. Of our many presidents, Richard Milhous Nixon was considered to be an expert on Foreign policy. ( ) Nixon, our 37th president, was born in 1913 in Yorba Linda, California. He attended Duke University where he received a degree in Law. He served as a Congressman and Senator for his California district. Two years later in 1952, General Eisenhower chose Nixon, to be his running mate. As Vice President, Nixon took on major duties in the Eisenhower Administration. Much of his term was spent on trips abroad as a goodwill ambassador meeting with foreign leaders to discuss world problems, representing the President to Congress, and to help mend ties between opposing countries. He was also a target for anti-American protestors. One of Nixon’s most memorable trips was to the USSR, to help open a United States exhibition in Moscow. Escorted by Nixon, Soviet Premier Nikita Khrushchev was taken through a model of an American kitchen. While walking through the kitchen both men began to discuss the relative merits of the United States and systems of Communism. This discussion would later o n be noted as the â€Å"Kitchen Debate.† ( ) In t...

8 Character Development Exercises to Help You Nail Your Character

8 Character Development Exercises to Help You Nail Your Character 8 Character Development Exercises to Help You Nail Your Character Even the most fast-paced, action-driven novels need compelling characters to keep readers engaged. Of course, readers will never â€Å"get to know† a character if the author doesn’t have a thorough understanding of who they are and what is driving them first. To this end, we’re about to get real close and personal with a few character development exercises.Character development exercises are a great way to give yourself a better understanding of the person you are creating with pen and paper (or â€Å"fingers and keyboard,† more likely). They also help you create resources that you can pull from during the writing process. In order to help bring your character to life, we are breaking character development down into three stages:Establish your character’s current emotional motivationsPut your character into contextBring your character to life Even the most fast-paced, action-driven novels need compelling characters to keep readers engaged. Establishing your character’s internal motivationsNailing down your character's fundamental goal - the thing that is truly important to them - will help you see what is driving them right now and why their story is worth telling at this moment in their lives. Without an internal goal to achieve, your story will lack a narrative arc. Perhaps even worse, your characters will come off as flat. How to Create a Character Profile: the Ultimate Guide (with Template) Read post Exercise #6: Break the iceThink about it: how many times have you been asked in one form or another, â€Å"So, tell me about yourself?† It’s a classic ice-breaker question, and, these days, with social media and the overwhelming variety of ways for us to â€Å"present ourselves† to the world, the stakes of â€Å"tell me about yourself† have never been higher. Of course, we change the way we answer this question based on who we’re talking to. Further chip away at your character and establish how they present themselves to others by imagining how they would briefly describe themselves in the following situations: In a job interviewOn a first dateCatching up with an old friendFlirting with someone at a partyIn their Twitter bioAt the border between the US and MexicoExercise #7: A little less conversation, a little more actionWhen you meet someone, you do not start by announcing your height, weight, hair, and eye color, so please do not introduce your c haracter to readers like this. But how to avoid describing looks and physicality without chunks of exposition? Consider this line from James Joyce’s Ulysses: â€Å"He looked in Stephen's face as he spoke. A light wind passed his brow, fanning softly his fair uncombed hair and stirring silver points of anxiety in his eyes.†Joyce takes advantage of a moment of action to shed light on Stephen’s looks and his anxious demeanor. Try your hand at conveying your character through action by first writing a list of physical traits that apply to your character. Next, with that list at hand, write a scene where something is happening - whether it’s a conversation, laundry-folding, cooking, etc. Weave references to your character’s physicality into the action.Exercise #8: Take them on a test-driveSometimes a bad case of writer’s block boils down to a broken connection between you and your protagonist, and the solution can be a change of scenery. Not for you - for your character! Writing prompts are a good way to get the creative juices flowing and can help you clear out the block so your character can continue down your story’s path.For a weekly supply of fresh writing prompts, head here. For your protagonist to shine through the page, they need to have their own voice. It’s only once you have acquired a thorough understanding of your protagonist, that a compelling and realistic character will shine through the page. However, there is disagreement in the world of writing communities regarding what information is or is not relevant for an author to know about a character. While we believe it’s probably unnecessary for an author know the number of hairs on their character’s head, we also believe you can never know too much about your protagonist. What’s important is discerning what information is significant to the current story you’re writing. As Ray Bradbury wrote in Zen in the Art of Writing: â€Å"Plot is no more than footprints left in the snow after your characters have run by on their way to incredible destinations.†If you’ve tried any of our suggested character development exercises, or if you have favorite tricks of your own, let us know in the comments!

Haute Couture Essay Example | Topics and Well Written Essays - 500 words

Haute Couture - Essay Example The late 1970’s were a time where interest in science fiction and the future was a common theme at the social level, with movies being launched such as Star Wars. The 1979 design illustrated the social demand for future lifestyle and innovation in fashion as well as showing the female clothing buyer as an important and respected part of international business. These suits were not created with explosive colours or other eye-catching patterns from previous years, rather the 1979 collection allowed simple, yet future-looking fabrics blend into design innovation in a way that was meaningful for mass market buyers and the female businessperson. A recent 2009 collection from Pierre Cardin reverts back to some of these design principles, using simple black and white and geometric patterns to create a stunning collection for women. The Appendix section shows an outfit which consists of dizzying explosions of black designwork throughout the collection which spirals like a liquid maze across the clothing. Key areas of sensuality on the female, including the hips and shoulders, are emphasised with sudden angular folds in the fabric which flair the outfit in key body locations. There are some significant differences to these different collections spanning 20 years, including the length of the hemline. In the 1970s, it was more acceptable to have longer skirts for business and even casual wear at a time where culture was emerging from more reserved moral and lifestyle values. This social aspect of lifestyle was added to the 1979 businesswoman collection and the outfit’s length was generally always below the knee. This fit within acceptable dress norms for the woman in business at the time. Today, however, Cardin has become more risquà © when redeveloping older styles for the new luxury consumer and has shortened the length of various dresses and suits to appeal to the more

Interdiction and Eradication of Drugs in the U.S Essay

Interdiction and Eradication of Drugs in the U.S - Essay Example The irony is that consumption of drugs has been on the increase, criminals are making more money from their annual turnover ranging from $ 400 to 500 billion. According to a confidential report from U.K. Government, only 20 percent out of 700 tons of Cocaine and 500 tons of Heroin illegally produced is being seized by enforcement forces. Supply being plentiful, prices are reported to be ruling low at $ 70 per gram today as against $ 184 in 1990. (Glenny 2007) This report is not alone. Similar observations. abound in the other Governmental reports and NGO studies Therefore the study gains significance in the wake of such reports to examine strengths and weaknesses of the Governments' policy initiatives towards interdiction and eradication of drugs. More so, because of opinions advocating legalizing the drugs besides the fact that policy initiatives focus on eradication of poppy cultivation without offering viable alternatives to the farmers concerned. The President rolls out National Drug Control Strategy for each year incorporating three key strategies namely (1) Stopping the Use before it Starts; (2) Intervening and Healing America's Drug Users; and, (3) Disrupting the Market. The Drug Budget for FY 2008 is $12.961 billion short of $0.167 billion from last year though it is compensated by additional request for $ 266 .1 million for emergency spending in Afghanistan.(National Drug Control Strategy). The Rand Report 2005 says that every year 16 million Americans forming 7 percent of the country’s population above the age of 12 consume about $60 billion worth of illegal drugs. And invariably the surveys on Americans have reveled that â€Å"drugs’† is one of the major ten problems of the country. ... (Caulkins P et al 2005 p 13) About 3 million drug consumers are affected by serious drug related problems and about 17,000 people have died due to problems illicit drug use in the year 2000 as against 20,000 in the year 1990. In 2003, 28,723 people have died for the same reason. (McVay) President's Drug Policy of Feb 2007 says that contrary to the reports in many quarters that drugs abuse has not been checked, performance records show a positive trend towards drugs control for the past six years ever since the present incumbent took office. As against the targeted reduction of drug abuse by 10 percent within 2 years and 25 percent within 5 years, administration claims to have achieved 11 percent and 23.2 percent respectively. And this was achieved by strategic benchmarking of each month's consumption. Figures beyond five years are even higher and in terms of number of youth who gave up drug use, it is 840,000. The lessons learnt during the last six years of the President's first of its kind National Drugs Control Strategy evidence that a sound policy can bring out results. Demotivating young users, identifying chronic consumers, maintaining vigil against steroid use for performance enhancement, and monitoring the use of other drugs such as Marijuana, Methamphetamin e, Amphetamine, pain relievers like OxyContin have been the features of the broad spectrum strategy of drugs control. Basically these will fall under the key elements of the above said prevention of drug use before its commencement by the potential users, intervention and healing of the people already on drugs, and disruption of the market for illegal drugs with the sole aim of reducing drugs consumption in the

Calcium In Contraction Of The Heart

Calcium In Contraction Of The Heart In cardiac muscle, excitation-contraction coupling is mediated by calcium-induced calcium release from the sarcoplasmic reticulum through ryanodine receptors that are activated by calcium entry through L-type calcium channels on the sarcolemmal membrane. Although Ca2+ induced Ca2+ release triggered by the L-typed calcium current is the primary pathway for triggering Ca2+ from the sarcoplasmic reticulum, there are many other mechanisms that can also activate Ca2 + release from the sarcoplasmic reticulum such as Calcium induced calcium release (CICR) induced by T-typed calcium current, CICR triggered by calcium influx through Na+/Ca2+ exchange, and CICR mediated by calcium through tetrodotoxin (TTX)-sensitive Ca2+ current (ICa,TTX). As calcium is an important second messenger which is essential in regulating cardiac electrical activity as well as being the main activator of the myofilaments to which cause cardiac contraction. Mishandling of calcium is thought to lead many pathophysiological conditions. Knowledge of the mechanisms involved in regulating intracellular calcium and therefore contraction of the heart, may help to prevent and/or treat pathological conditions such as cardiac hypertrophy, arrhythmias or heart failure by using therapeutic agents targeted at modulating intracellular calcium. ACKNOWLEDGEMENT Firstly, I would like to show my deepest gratitude to my supervisor, Dr. Munir Hussain, who is a Senior Lecturer in Biomedical Sciences in University of Bradford for his innovative, supportive, expert, professional, kind and careful supervision, constant guidance and, academic support. Without his advice and guidance, my dissertation will not be finished with great success. I would also like to show my sincere thank to all the lecturers from Management Development Institute of Singapore (MDIS) and teachers in my student life for letting me gain strong knowledge in biomedical science field and essential knowledge to be in this stage and my student coordinator and stuffs from Student Service Unit (SSU) for their kind arrangement, support, encouragement and care. I would like to thank to all my friends who supported me both physically and mentally during my preparation for the dissertation. Last but not least, I would like to convey my special deep thank to my parents who always give me tender love, care and all supports all the time. Without their guidance, support and love, nothing can be achieved by me. LIST OF FIGURES Figure 1: Calcium transport in ventricular myocytes 3 Figure 2: Six possible mechanism of cardiac excitation-contraction coupling 9 LIST OF ABBREVIATIONS LTCC = L-type calcium channels CICR = Calcium induced calcium release ECC = Excitation-contraction coupling NCX = Sodium-Calcium Exchange SR = Sarcoplasmic Recticulum ICa = Calcium current ICa,T = T-type calcium current ICa,L = L-type calcium current ICa,TTX = Tetrodotoxin-sensitive calcium current RyRs = Ryanodine Receptor [Ca2+]i = Intracellular calcium concentration [Ca2+]Tot = Total concentration of Calcium PKA = Protein Kinase A LVH = Left Ventricular Hypertrophy HOCM = Hypertrophic obstructive cardiomyopathy Introduction In heart muscle cell, the depolarization of action potential is due to the entering of Na+ ions via voltage gated Na+ channels and it is called fast inward current. The immediate repolarization is not possible due to rapidly inactivation of Na+ channel and initial depolarization allow the entering of calcium through voltage-grated Ca2+ channels and it is called second or the slow inward current. The rate of sodium channels inactivation is more rapid than that of calcium channels so that Ca2+ enters into the cell providing the membrane potential to close to 0mV for some part of action potential of heart muscle (Reuter, 1984). Excitation-contraction coupling (ECC) is the process in which an action potential triggers a myocyte to contract. In excitable muscle cells, the excitation signal causes rapid depolarization that produces the physiological response of contraction. Calcium is a ubiquitous second messenger, important in both, regulating the electrical activity of the heart as well as stimulating the myofilaments directly to cause contraction (Bers, 2001). In mammalian cardiac myocytes, the process of ECC is mediated by Ca2+ influx from the extracellular space that triggers Ca2+ Calcium induced Calcium release (CICR) from the sarcoplasmic reticulum (SR) (Bers, 1991; Stern Lakatta, 1992). When action potential reaches the myocyte, causing it to undergo depolarization, which causes calcium ions to enter the cell through L type calcium channel located on the sarcolemma and thereby trigger calcium release from the SR. Calcium influx and the intracellular calcium concentration trigger the contraction of heart due to binding of Ca2+ to cardiac muscle fiber protein, troponin C. For activation of SR calcium release, the L-type calcium current is the most widely accepted mechanism thought to be responsible for CICR. However, SR calcium release can also be triggered by calcium influx through sodium-calcium exchange, calcium influx via T-type Ca2+ current or through tetrodotoxin-sensitive Ca2+ current, or Inositol (1,4,5)-triphosphate (but not so much in cardiac muscle). Declining of calcium level in the cells cause the detachment of calcium from myofilament and resulting in relaxation of the heart. There are four main pathways for Ca2+ transport out of the cytosol including SR Ca2+ ATPase, sarcolemmal Ca2+-ATPase or mitochondrial Ca2+ uniport and sarcolemmal Na+/Ca2+ exchange. (Bers, 2002). Since CICR is a positive-feedback mechanism, it has to be terminated which is essential for diastolic refilling of the heart. There are three main pathways for termination of calcium release such as local depletion of SR Ca2+, Ryanodine ( RyR) inactivation (or adaptation), and stochastic attrition. (Lukyanenko et al., 1998). Mutation in calcium channels can lead to life-threatening arrhythmias. The improper contractile function and abnormal heart rate associated with cardiac hypertrophy and heart failure is due to the mishandling of calcium in heart muscle cell (Pogwizd et al., 2001). In this dissertation, here I discuss about the key mechanism of how Ca2+ transport in cardiac ventricular myocytes. Moreover, I also discuss about how they are modulated and regulated as well as how they interact specifically. In addition, by knowing the subcellular mechanism of E-C coupling, here I discuss about how calcium is altering and getting mutated so as to cause cardiovascular diseases. The imp ortant molecular signaling pathways in contraction of heart will also be addressed. Figure 1. Calcium transport in ventricular myocytes. (Adapted from Bers, 2002) The figure shows the time course of an action potential, Ca2+ transient and contraction in rat ventricular myocytes, NCX, and other protein involved in contraction. Calcium channels in contraction of the heart In cardiac muscle, calcium has a role for the ability to make the cardiac cell to contract. There are five types of calcium channels; L, T, N, P/Q and R types. Among them, L-type and T-type calcium channels are two major types of calcium channels in the cells of cardiac tissues (Bean, 1989). L-type Ca2+ channels have many subunits in the heart such as ÃŽÂ ±1, ÃŽÂ ±2, ÃŽÂ ´ and ÃŽÂ ² subunits. The ÃŽÂ ±1 subunit is the dihydropyridine (DHP) receptors which are important for calcium entry into the cells (Liu et al., 2000). L-type calcium channels (long-lasting) can activates at more positive membrane potential (Em), at greater than -40mV and generate peak inward current at 0mV and slowly inactivated, and is sensitive to dihydropyridines (Tsien et al., 1987). Thus, the L-type Ca2+ channels are the majority of calcium channels responsible for entering of Ca2+ into the cardiac cell during phase 2 (plateau phase) of the action potential. On the other hand, T-type (tiny or tr ansient) Ca2+ channels cause the activation and inactivation at more negative membrane potential (Em) and dihydropyridines cannot block effectively (Nowycky et al., 1985). However T-type Ca2+ channels have faster kinetics than compared to L-type Ca2+ channels. During development and hypertrophy, T type calcium current is more prominent and the T-type current is typically small or absent in ventricular myocytes. The entering of Ca2+ into the cell by passing through I Ca,T is only responsible for smaller amount of Ca2+ than that passing through ICa,L. In most ventricular myocytes, T-type calcium current is almost negligible. It shows that the releasing and refilling is mainly provided by Ica,L. The amount of L-type calcium current and T-type calcium current is variable among cardiac myocytes. L-types calcium current is present in all cardiac myocytes whereas T-type calcium current have larger component in the canine Purkinje fiber (Zhou, 1998). Depolarization during the action potent ial causes activation of calcium current. During an action potential, the amount of calcium entry is limited by calcium dependent inactivation at the cytosolic side. L-type calcium channel is located at the sarcolemmal-SR junction where ryanodine receptors exist (Scriven et al., 2000). There is a negative feedback effect on Ca2+ influx and SR Ca2+ release during excitation-contraction mechanism. When there is increased Ca2+ influx or release, further release of Ca2+ is turned off. There are many isoforms of ryanodine receptors, (RyR1, RyR2, RyR3), among them, RYR2 is the cardiac isoform. RyR2 mediated release of Ca2+ from sarcoplasmic recticulum is an important step in cardiac E-C coupling in the heart. RyR2 is a Ca2+-gated channel (Nabauer et al, 1989). RyR2 is activated by Ca2+ influx through L-type Ca2+ channel or dihydropyridine receptor (Adachi-Akahane, 1996). Cytosolic Ca2+ is increased by the RyR2 opening and bind with contractile protein (troponin C) that trigger the contraction of heart. In ventricular myocytes, there are much more ryanodine receptors than dihydropyridine receptors. Therefore, four or ten RyRs can be associated with a single L-type Ca2+ channel (Bers et al., 1991). Defection in excitation- contraction coupling can occur due to either if RyRs channels sensitivity is altered for activation/inactivation or if the SR Ca2+ is depleted. There has been demonstrated in animal model of cardiomyopathy (Gomez et al, 1997). [Ca2+]i and Ca2+sparks [Ca2+]i and total [Ca2+] determine the development of contraction which produces both isometric force and rapid shortening (Moss, 2001). The strength of cardiac contraction can be changed by two ways: (1) by changing the extent and amplitude of the Ca2+ transient, (2) by altering the myofilament sensitivity to Ca2+. The sensitivity of myofilament calcium is increased by contracting the myofilament when the heart fills with blood resulting the contraction to be stronger. Caffeine and certain inotropic agents can enhance the myofilament sensitivity whereas the increased concentrations of phosphate and Mg2+ and acidosis reduce myofilament Ca2+ sensitivity. Ca2+ sparks is the process of spontaneous release of SR Ca2+ and it was described by using confocal fluorescence microscopy (Cheng et al., 1993). The release of SR Ca2+ via single L-type Ca2+ channel or RyRs openings generates Ca2+ sparks (Song et al., 1997). Ca2+ spark is activated by the Ca2+ entery through ICa (Cannell et al, 1995) . Ca2+ spark is triggered by the opening of single channel opening. There have been reported that spark probability can be depend on binding of two Ca2+ ions to the RyR (Santana et al., 1996). Thus, local cytosolic [Ca2+]i is important in the frequency of Ca2+ sparks and SR Ca2+ release. Moreover, the frequency of Ca2+ spark depends on the SR Ca2+ load (Cheng et al, 1993). When there is increased SR Ca2+ load, this may lead to increase the amplitude of Ca2+ spark. Therefore SR Ca2+ load is an important factor for Ca2+ release from SR. Role of Sarcoplamic Recticulum ECC and intracellular Ca2+ homeostasis are primarily regulated by sarcoplasmic recticulum (Bers, 1991). Once stimulation, calcium enters the cell, thereby stimulating the release of larger amount of calcium from SR resulting in activation of contractile protein and contraction of the heart. During cardiac relaxation, Ca2+ is taken up by SR by SR Ca2+ ATPase pump and Na+/Ca2+ exchange pump. The key SR Ca2+ release channel involved in cardiac contraction is RyRs and RyR2 is the cardiac isoform. The amount and fraction of Ca2+ release that depends on the level of SR Ca2+ load can release for a given ICa trigger (Shannon et al., 2000). Sensitivity of RyRs receptor to [Ca2+]i at high load of SR Ca2+ leads to increase spontaneous SR Ca2+ release. On the other hand, decrease in SR Ca2+ release (which is induced by ICa ) can be due to low SR[Ca2+] content. The lower the amount of the SR Ca2+ release, the more amount of Ca2+ enter the cells through Na+/Ca2+ exchange. When there is low concent ration in SR Ca2+, Ca2+ release from SR is turned off during E-C coupling. Furthermore, SR Ca2+ content depends on the heart rate and duration of action potential. Ca2+ concentration release from SR can be increased by more mount of Ca2+ enter into the cell, by decreasing Ca2+ efflux or increasing SR Ca2+ uptake. Phospholamben, an endogenous inhibitor of SR Ca2+ ATPase, is triggered by activation of cAMP-dependent or calmodulin-dependent protein kinase. When this phospholamben becomes phosphorylated, Ca2+ uptake by SR is increased and allows faster cardiac relaxation and declining of [Ca2+]i. Targeted knockout of phospholamben leads to hyperdynamic hearts with negative effects (Brittsan Kranias, 2000). Interestingly, lower SR Ca2+ uptake, reduced SR Ca2+ATPase gene and protein expression were seen in failing human heart (Pieske et al., 1995). On the other hand, there has been demonstrated that increased gene expression of sarcolemmal Na+/Ca2+ exchanger was seen in human failing hea rt (Reinecke et al., 1996). Regulation of Calcium current Ica can be variable physiologically and pharmacologically. During physiological sympathetic stimulation of heart, catecholamine stimulate beta-adrenegic receptors, which improve the force of contraction (inotropic effects) and relaxation (lusitorpic effects) and declining of [Ca2+]i. In addition, stimulation of ÃŽÂ ²-adrenergic receptor stimulates a GTP-binding protein that accelerates adenylyl cyclase for the cAMP production. cAMP activates PKA, which phospharylates severe protein such as phospholamban, RyR, L-types Ca2+ channels, myocin binding protein C and troponin I ( which are related to ECC). Activation and phosphorylation of L-type Ca2+ channels will cause Ca2+ release from SR causing contraction of the heart. Phosphorylation of troponin I and phospholamban stimulate the reuptake of Ca2+ release from SR and Ca2+ is dissociated from the myofilament and develops to cardiac relaxation (Lusitropic effect). The inotrophic effect of PKA (protein kinase A) activation is triggered by the combination greater availability of SR Ca2+ and increased calcium current. Open probability of RyR channels can also be modulated by protein kinase A. RyRs receptors are hyperphosphorylated in heart failure causing a diastolic leak of SR Ca2+. However, whether PKA-dependent phosphorylation will alter during excitation-contraction or not still remain controversial. Moreover, phosphorylation of L-type Ca2+ channels, phospholamban and troponin I are paralleled with activation of ß1-adrenergic receptors in ventricular myocytes that produce inotrophic and lusitropic effects. On the other hand, ß2-adrenergic receptors activation can give more restricted to the enhancement of ICa (Kushel et al., 1999). cAMP production can also be stimulated by the G-protein-coupled receptors such as prostaglandin E and histamine that will lead to little or no effect of inotropic effects (Vila Petroff et al, 2001). Other receptors will also regulate the signaling pathway. For instance, M2-musc arinic receptors activation can decrease cAMP and activation of PKA thereby decreasing Ca2+ entry and release. In addition, this pathway also enhances repolarization. The pharmacological effects of L-type Ca2+ channels are in which calcium sensitivity to dihydropyridines (nephedipine, amlodipine, nitrendine, nimodipine, nisoldipine). Ica is inhibited by most of DHPs and they are called Ca2+-channel blockers. In DHPs, there are two other types of specific L-type Ca2+ channel blockers (1) phenyalkylamines (eg. verapamil, D600) and (2) benzothiazepines (eg, diltiazem), and those agents can act together directly with the Ca2+ channel (Glossmann et al., 1985). Verapamil can inhibit the calcium channel in the open state but it require depolarization pulse) and this is called use dependent. The neutral ligands such as nitrendipine and nisoldipine inhibit ICa depend on the calcium channel whether they are in the opening state or inactivated state , and does not require depolarization pulse as they are voltage dependent than use dependent. Figure 2. Six possible mechanism of cardiac excitation-contraction coupling. (Adapted from Bers, 1999) The figure shows Ca2+ influx via ICa,L, Ca2+ influx via ICa,T,Ca2+influx through NCX, Ca2+ influx via IP3 ,Ca2+ influx via ICa,TTX and depolarization dependent Ca2+ influx. Calcium induced calcium release during E-C coupling There have been demonstrated that CICR in skinned ventricular myocytes (Fabiato and Fabiato, 1975). There was been proved that main pathway of E-C coupling in cardiac myocytes is by Ca entry through L-type Ca2+ channels and triggers SR Ca2+ release (Bers, 1991). When calcium channel becomes deactivates, before calcium channels close, calcium transient is induced by a large and short-lived ICa causing contraction. Moreover, Ca2+ channel activation in the absence of Ca2+ influx also cannot induce calcium release from the SR (Nabauer et al., 1989). There is supported that ICa activate SR Ca2+ release channel when there is a high concentration of Ca2+ buffer in the cell (Adachi-Akahane et al., 1996). Ca2+ release from SR is most commonly activated by L-type Ca2+ channels and this pathway is called Ca2+ induced Ca2+ release (CICR). There has been little doubt that E-C coupling occurs physiologically but there are other mechanisms which can exit in parallel and give rise to the functional effects. Ca influx via ICa,T In ventricular myocytes, T-type calcium channels is relatively small or absent but it is more prominent in the development and hypertrophy of the heart. Because of T-type calcium current is relatively small and rapidly inactivated, the total amount of calcium influx through T-type calcium current is absolutely small compared to calcium influx via ICa,L (Zhou, 1998). Moreover, T-type calcium current is negligible in most of ventricular myocytes. T-type Ca2+channels are not located at the SR junction, therefore the effectiveness of ICa,T as a trigger for Ca2+ release from SR is not effective as ICa,L. Furthermore, SR Ca2+ release by ICa,T is delayed on onset and slower than ICa,L. However, it can be significant in other cardiac cells such as some atrial cells and Purkinje fibers (Zhou and January, 1998). Since T-type calcium channel is non-functional in most of the myocytes of ventricle, it does not play a major role for ECC although it may function like ICa,L. So, ICa,T only plays a m inor role in triggering Ca2+ release from SR during action potential. Ca influx via Na+/Ca2+ exchange Although L-type Ca2+ current is a major role of CICR in contraction of the heart, some argued that the L-type Ca2+ channels could not be the only way to trigger the calcium release from SR. There is an alternative trigger of calcium release in mammalian cardiac myocytes (Chunlei Han et al., 2002). The result of Ca2+ release by Na+/Ca2+ exchanger has been proved by examination on rats (Wasserstorm and Vites, 1996), rabbit (Litwin et al., 1998) and guinea pig (Sipida et al., 1997). Immunofluorescence labeling shows that the exchanger current is present in the cardiac T-tubules system (Scriven et al, 2000). There are two ways of triggering Ca2+ release from SR by Na+/ Ca2+ exchanger. The first mechanism is Na+ current by increasing local [Na+]sm, increasing Ca2+ entry through Na+/Ca2+ exchanger and causing SR Ca2+ release (Levesque et al.,1994 ). The second one is that depolarization directly stimulates outward INa/Ca and Ca2+ release and contraction when L-type Ca2+ channel become bloc ked or at high positive Em (Levi et al.,1994 and Litwin et al.,1998 ). Increased intracellular sodium stimulate the Na+/Ca+ exchanger (Evans and Cannell, 1997 ) and, if INa is low ([Na+]i=10nM) or lower, the reverse current of the Na+/Ca2+ exchange could trigger Ca2+ release account for 25%. When [Na+]i=30nM, the contribution of Na+/Ca2+ exchanger increase up to 100%. Additionally, the exchanger current is more dependent on the temperature and changes in the intracellular sodium and calcium concentrations than compared to L-type calcium current. Furthermore, these changes are larger in the microdomain or subspace (interaction between RyR receptors and L-type Ca2+ channels occurs) than compared to the rest of the cytoplasm (Vornanen et al., 1994). Although LTCC are faster than the exchanger current in triggering of Ca2+ release from SR, Ca2+ entry through the exchanger into the subspace is faster in beginning than L-type Ca2+ current when there is action potential stimulations becaus e the action potentials upstroke and sodium (inward) current is associated with rapid increase in [Na+]i. Therefore, any physiological stimulation or medication that alters the intracellular sodium becomes the regulator of calcium release from sarcoplasmic reticulum. Stimulation via hormone, such as activation of endothelin-1 (ET-1) receptor (Alvarez et al., 1999), and increasing frequency of action potential (Simor et al., 1997) will increase the intracellular sodium concentration, causing calcium release triggering via the Na+/Ca2+ exchanger by opposing to via the L-type calcium current. Ca2+ release from SR is slower via Ca2+ influx through Na+/Ca2+ exchanger than through L-type calcium channel (Spido et al., 1997) . Ca influx via TTX sensitive-Na channels Aggarwal and co-worker reported voltage-gated, calcium conducting sodium channel, (ICa,TTX), calcium entry via tetrodotoxin-sentive Na+ channels can also mediates CICR. This channel activates at membrane potential of -60mV and has faster kinetics than L-type Ca2+ channels. It can alter selectivity of cardiac Na+ channels triggers by either activation of agonist effects ÃŽÂ ²-adrenergic receptor or cardioactive steroids or cardiac glycosides, resulting Na+ channel prefer Ca2+ than Na channels and it is called slip mode or altered selectivity mode. The tetrodotoxin-sensitive Ca2+ influx can also trigger the SR Ca2+ release. The inotrophic effects of cardiac glycosides and ÃŽÂ ²-adrenergic agonists could be a novel mechanism. These effects could be triggered by SR Ca2+-pump activity and increased ICa or by Na+/K+ ATPase inhibition and also decreased Ca2+ efflux through Na+/Ca2+ exchange for cardiotonic glycosides (Borgatta et al., 1991). Moreover, one study in rat ventricular myoc ytes reported that Na+ current is activated by the phyosphoryation by protein kinase A or by the cardiotonic steroids. (slip mode conductance) (Santana, 1998). In addition, modified Na+currents conduct ICa,TTX which in turn triggers CICR. The relation between slip mode conductance and ICa,TTX is still controversial (Nuss, 1999). On the other hand, another study demonstrarted that Ca2+ current due to ICa,TTX or slip mode conductance is not related and identical. The reason is that the presence of cardiac steroids or activation of PKA is not a requirement for the detection of ICa(TTX). A small fraction of Na + currents can conduct ICa(TTX) even without phosphorylation of PKA (Nuss, 1999). Furthermore, TTX sensitive-Na+ channels cannot be inhibited by the blockers of T-type or L-type Ca2+ channels. Recently, one of studies showed that ICa(TTX) and T-type Ca2+channel coexit in guinea pig venricular myocytes because 10 mM mibefradil could block both ICa(TTX) and T-type Ca2+current (Heuba ch, 2000). Although this current is not the major current for triggering the CICR, its possible functional roles are important in normal heart cells such as promoting the sodium current activation and modulating rhythmicity of the heart. Ca influx via IP3 pathway Inositol (1, 4, 5) triphosphate could trigger Ca2+ release from SR and endoplamic reticulum in different cell types, they are called IP3 receptors. In ventricular myocytes, the major form of InsP3 is isoform 2 (Lipp et al., 2000). There are more InP3 receptors in atrial cells in ventricular myoctyes. Stimulation of IP3 signal transduction pathway can trigger the release of Ca2+ from SR via IP3 receptors which is located on SR. Even high concentration of InP3 in cardiac myocytes could trigger Ca2+ release from the SR, the extent of Ca2+ release from the SR are so much lower than CICR triggered by LTCC. Moreover, action potential cannot stimulate the InP3 production (Kentish et al., 1990). The production of InP3 contractile force is increased by cardiac alpha-adrenergic and muscarinic agonists (Poggioli et al., 1986). In addition, InP3 pathway only plays a very little minor role in cardiac EC coupling. To conclude for triggering Ca2+ release from SR, CICR in cardiac contraction is mai nly through L-type Ca2+channel.Other mechanisms that mentioned above show minor role in SR calcium release. Cardiac relaxation During an action potential, calcium entry into the cell is slow at the end of phase 2 and there is lowering of the cytosolic calcium concentration because calcium is taken back by the SR and removing of calcium from the troponin C and finally initial sarcomere length is restored. For relaxation and cardiac ventricular filling, Ca2+ have be removed from the cytosol to lower [Ca2+]i , causing relaxation. Cardiac relaxation to occur, Ca2+ must be dissociate from troponin C and it requires Ca2+ transport out of the cytosol primarily by four main pathways involving, sarcolemmal Na+/Ca2+ exchange, SR Ca2+-ATPase, sarcolemmal Ca2+-ATPase or mitochondrial Ca2+ uniport. There are selective inhibition for each transporter during cardiac myocyte relaxation and [Ca2+]i decline (Puglisi et al., 1996). SR Ca2+ uptake can be prevented by either thapsigargin or caffeine, complete removal of extracellular Na+ and Ca2+ can prevent sodium calcium exchange. Either carboxyeosin or elevated [Ca2+]i inhibi t sarcolemmel Ca2+-ATPase, and mitochondrial Ca2+ uptake can be inhibited by rapid dissipation of the electrochemical driving force for SR Ca2+ uptake by using protonophore FCCP. In rabbit ventricular myocytes, 70% of the activated Ca2+ removed by the SR Ca2+-ATPase from the cytosol, whereas 28% was removed by NCX, only 1% for sarcolemmal Ca2+-ATPase as well as mitochondrial Ca2+ uniporter remove 1% of calcium from SR ( the last two pathways are called slow systems). In rat ventricular myocytes, SR Ca2+-ATPase activity is higher due to more pump molecules in unit cell volume (Hove-Madsen Bers, 1993). On the other hand, Ca2+ removal via Na+/Ca2+ exchange is lower, 92% with SR Ca2+-ATPase, 7% with NCX, the slow systems with 1 % respectively. In mouse ventricular myocytes, the uptake mechanism is quite similar to rat, (Li et al., 1998) while the mechanisms of Ca2+ fluxes in human ventricular myocytes, guinea pig and ferret are more similar to rabbit myocytes (Pieske et al., 1999). In contraction and relaxation of myocytes, the amount of calcium removed from the cell during relaxation must be the same as the amount of calcium entry during contraction in each heart beat, if not, the cell may gain or lose the calcium. Defects in Ca2+ removal also can cause impair relaxation Termination of calcium release Although CICR is a positive-feedback mechanism, termination or turning off of the Ca2+is important for diastolic refilling of the heart. There are three major ways for terminations of Ca2+release include local SR depletion, RyR inactivation or adaptation and stochastic attriction (Sham et al.,1998; Lukyanenko Gyorke,1998). Stochastic attriction means L-type Ca2+ channels and all RyRs are closed simultaneously, then local [Ca2+]i will drop quickly to the sub-threshold level and disturbing the release from SR . However, this is only used for 1DHPR and 1-2 RyRs whereas they all will not close at once for other types of channels. In addition, local depletion of SR Ca2+ also may terminate SR Ca2+ but it cannot completely turn-off of release, because very long lasting Ca2+ sparks are found that will not decline with time (Satoh Bers, 1997). However other regions of SR can also limit local SR Ca2+ depletion. During a global Ca2+ transient, the whole SR Ca2+ declines. During a relaxation, SR Ca2+ depletion could lead to the turning -off global SR Ca2+ release. There are two types of RyR inactivation both of which depend on [ Ca2+ ]i .One of them is absorbing inactivation ( for example like Na+ channels), in which the ryanodine receptor cannot reopen until it recovers (Sham et al., 1998; Lukyanenko Gyorke, 1998). The another one is called RyR adaptation in which ryanodine after activation leads to a reduced open probability, but it can be reactivated by higher [Ca2+]i (Valdivia et al.,1995). RyRs inactivation could be important in reducing SR Ca2+ release events between each heart beats. To summarize, Ca2+ release during ECC is terminated mainly by a local RyRs inactivation and partial SR luminal Ca2+ depletion which leads to reduce RyR openings and variant of stochastic attrition also contributes. Role of calcium channels in cardiac hypertrophy, heart failure and arrhythmia Intracellular calcium is the major regulator of cardiac contraction. Therefore, altered cardiomyocyte regulation is important in arrhythmogenesis, cardiac mechanical dysfunction and cardiac hypertrophy associated with heart failure. Alteration in signal transduction pathways can also lead to loss of inotropic effects in heart failure. Defects in ECC have been reported in animal models of cardiomyopathy (Gomez et al., 1997). There is no E-C coupling depression was seen in pressure overload of cardiac hypertrophy with less sign of heart failure. (Rios et al., 1992). Cardiac hypertrophy is the enlargement and thickening of the heart muscle resulting in decreasing size of the chamber of the heart. Cardiac hypertrophy is the main cause of cardiac morbidity and mortality in cardiovascular system. It is associated with heart failure without myocardial infarction. Cardiac hypertrophy is associated with significant changes in myocardial contraction. These contractile dysfunctions are followed by changing in the whole-cell intracellular calcium transient. The pathogenesis and etiology of cardiac hypertrophy and heart failure related with the role of Ca2+ channels still remains controversial. of ÃŽÂ ² subunits of L-type Ca2+ channels (LTCCÃŽÂ ²) enhances the probability of channels opening as well as also favours the trafficking of the Ca2+ channels to the surface membrane leading to increase calcium current (Chen Y.H, 2004). Interestingly, there has been reported upregulation of LTCCÃŽÂ ² in failing human cardiomyocytes (Hullin et al, 2003). In aortic banding, L-type Ca2+ channels concentration is remain unchange in rats myocytes with hypertrophy ( Scamps et al.,1990), cats with pulmonary artery banding (Kleinman, 1988) cardiomyopathy in Syrian hamsters (Sen, 1994) ,and ventricular

Narrative Argument About Education Religion Essay

Considering the gift of computers Bill Gates bestowed upon libraries for students, I’m sure his intentions were for the students to excel and keep abreast of the ever changing world of technology, not to replace reading with surfing the web. I agree with Judith Levine when she stated, â€Å"It’s important for students to read books, magazines, newspapers, history, poetry, politics and listen to people who know what they’re talking about.† Reading books and other literature teaches students the past, present and future, not only for things happening in the world today but facts about things past. Dating myself, I think back to the days of the sixties and seventies when reading was fundamental to education. Literacy was important and the only choice we had was to read a book because there were no computers. Teachers took us to the library weekly, and we were required to check out at least one book and read it. There was also time set aside during class for u s to stand up and read a portion of your book aloud. Most of our books had no pictures to stimulate the imagination, so you felt a sense of accomplishment when the book was finished. Teachers took education very serious, and they knew reading was essential to be successful in life; therefore, they made sure we took it serious as well. When we read a story for a writing assignment, our first resource was the encyclopedia, which was neatly stacked inside the bookcase in almost every home. There were no short cuts to obtaining information. Reading is more empowering than one-click learning; you develop increased discernibility and critical thinking skills. Computers are a great tool. I use one every day for my online college courses and I know how important it is to question everything I retrieve on the internet. Computers, however, have made students slack  and lazy. From a very young age children have developed the attitude of not liking to read and with computers supplying all the answers for them, they don’t have to. As I sit and look at my blank computer screen, and time is ticking away until my essay is due, I read my story once again. I also head for the web, but only to get ideas and something to assist me with my starting point. Nothing takes the place of old fashioned reading. I know my subject is education and my story is talking about computers, so I google education using computers. One site – Using Technology: Ways to use Computers/Education.com – catches my eye, but after accessing the site I soon find this is not the site or the data that’s going to help me prepare a creditable paper. So I reread my story and the instructions, put my critical thinking cap on and choose not to one stop shop for my assignment. I begin writing everything I can think of and soon the ideas surface. This is unlike inexperienced users, like our children and grandchildren, who rely heavily on data they retrieve from the internet without considering how much weight the site is going to hold, and what kind of argument the data will present to their readers who may feel they did not provide enough information about the topic. Our students have become accustom to presenting data found on the web as fact, giving no thought to how bias the information might be . Some even portray the data as their own, without verifying its validity. Parents need to share some of the responsibility, because we are not teaching our children the difference between working hard and hardly working. From a Biblical perspective Deuteronomy 6: 4-9 states: â€Å"Hear, O Israel: The Lord our God, the Lord is one! You shall love the Lord your God with all your heart, with all your soul, and with all your strength. And these words which I command you today shall be in your heart. You shall teach them diligently to your children, and shall talk of them when you sit in your house, when you walk by the way, when you lie down, and when you rise up. You shall bind them as a sign on your hand, and they shall be as frontlets between your eyes. You shall write them on the doorposts of your house and on your gates†. This command from God explains why education is important, and why it is our responsibility as parents to educate our children, both academic and Biblically. My eighty-three year old Uncle Mike was a prime example of why getting an education is important. He only had about an eighth grade education and virtually no Biblical  knowledge. Because of his limitations, he was never able to make a decent living throughout his life. He also had no knowledge of who God was and expressed no desire to be saved. His soul was doomed to hell; however, I never gave up on Uncle Mike. I knew it was God’s will that everyone be saved, and on July 28th, 2013, his eyes were opened, and his heart soften as he accepted Jesus Christ as his Lord and Savior two days before he passed away. In conclusion, computer use has caused us to no longer read books or utilize our critical thinking skills. Our students have become slack and lazy and collect unreliable data to present as facts. We must guide and teach them how to surf the web and to become better readers, which in turn, will make them better writers. References Levine, J, â€Å"I Surf, Therefore I Am†, in To the Point, Reading and Writing Short Arguments, 2nd, 222-224. Pearson Education, Inc. 2009 MacArthur Study Bible NKJV (1997) Word Publishing, a division of Thomas Nelson Inc. Narrative Argument about Education Thesis/Outline Topic: Education and Computers Thesis Statement: The everyday use of computers has caused us to become slack and lazy. We no longer read or utilize our critical thinking skills. The inexperienced user collects unreliable data, and presents them as fact. Outline: I. Introduction Reading vs Computers II. Body Paragraphs A. Author argument B. Education Importance C. Alternative to Computers D. Biblical Perspective. Conclusion Computer use has caused us to no longer read or utilize of critical  thinking skills.

Essay on Womens Role in Society in the 1800s - 728 Words

AP American History Women’s Role in Society During the early 1800s women were stuck in the Cult of Domesticity. Women had been issued roles as the moral keepers for societies as well as the nonworking house-wives for families. Also, women were considered unequal to their male companions legally and socially. However, women’s efforts during the 1800’s were effective in challenging traditional intellectual, social, economical, and political attitudes about a women’s place in society. The foundation of colleges for women as well as events at women’s rights conventions intellectually challenged society’s views on women’s traditional roles. As education became more of a public governmental service, the educational†¦show more content†¦Women’s rights activists influenced the nation to believe that women were men’s equals, changing traditional women social roles. During the 1800’s a husband had legal authority over their wife. In a sense, he owned her, and for that reason women had little respect in their culture. However, as women pursued their cause for equal rights, many men began to see women as their equals. This gained them greater respect within their culture. An example of one of the social changes that occurred because of women’s rights movements was when Lucy Stone kept her maiden name even after she became married. Fifty years before the women’s rights movements began a small event like this w ould have never been allowed within the community. As women in the 1800’s fought for women’s rights, slowly female social roles began to change. With the help of the Industrial Revolution, women made significant strives in changing the traditional economic roles given to females. Before the industrial revolution the only opportunity for a woman to be financially secure was for that woman to marry a financially secure husband. 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